Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma RUNNING HEAD MRD assessment by sequencing in multiple myeloma AUTHORS AND AFFILIATIONS
نویسندگان
چکیده
Hospital Universitario 12 de Octubre, Madrid; Sequenta, Inc., South San Francisco, United States; Hospital Universitario de Salamanca-IBSAL, IBMCC-CSIC, Salamanca, Spain; Clínica Universitaria de Navarra, Centro de Investigación Médica Aplicada (CIMA); Hospital Clínic i Provincial de Barcelona, Institut d'Investigacions Biomédiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Hospital Germans Trias i Pujol; Hospital Ramón y Cajal; Hospital Clínico de Madrid Blood First Edition Paper, prepublished online March 19, 2014; DOI 10.1182/blood-2014-01-550020
منابع مشابه
Novel therapeutic agents for the management of multiple myeloma patients with renal impairment Running head (max 50 characters): Management of MM patients with renal impairment Authors:
Author affiliations: Roswell Park Cancer Institute, Buffalo, NY; Hospital-CIC, Universidad de Salamanca/CSIC, Salamanca, Spain; The Tisch Cancer Institute, Mount Sinai Medical Center, New York, NY; 1st Department of Medicine, Center for Oncology and Haematology, Wilhelminenspital, Vienna, Austria; University of Athens, School of Medicine, Athens, Greece *Current affiliation: Division of Hematol...
متن کاملIncreased incidence of non-Hodgkin lymphoma, leukemia and myeloma in patients with diabetes mellitus type 2: A meta-analysis of observational studies Short title Diabetes and leukemia, lymphoma and myeloma Authors
Affiliations (1) The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Rhode Island Hospital/The Miriam Hospital, Providence, RI, USA (2) The Warren Alpert Medical School of Brown University, Department of Medicine, The Miriam Hospital, Providence, RI, USA (3) Tufts University Medical School, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical ...
متن کاملHuman Cancer Biology Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow
Purpose: In myeloma, B cells and plasma cells show a clonal relationship. Clonotypic B cells may represent a tumor-initiating compartment or cancer stem cell responsible for minimal residual disease in myeloma. Experimental Design:We report a study of 58 patients with myeloma at time of diagnosis or relapse. B cells in bonemarrowwere evaluated bymulticolor flow cytometry and sorting. Clonality ...
متن کاملHuman Cancer Biology Protein KinaseCK2ProtectsMultipleMyelomaCells fromER Stress–Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response
Purpose: Protein kinase CK2 promotes multiple myeloma cell growth by regulating critical signaling pathways. CK2 also modulates proper HSP90-dependent client protein folding and maturation by phosphorylating its co-chaperoneCDC37. Because the endoplasmic reticulum(ER) stress/unfoldedprotein response (UPR) is central in myeloma pathogenesis, we tested the hypothesis that the CK2/CDC37/HSP90 axis...
متن کاملCancer Therapy: Preclinical Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma
Purpose: The aim of the study was to verify the hypothesis that the cMet oncogene is implicated in chemioand novel drug resistance in multiple myeloma. Experimental Design: We have evaluated the expression levels of cMET/phospho-cMET (p-cMET) and the activity of the novel selective p-cMET inhibitor (SU11274) in multiple myeloma cells, either sensitive (RPMI-8226 andMM.1S) or resistant (R5 andMM...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014